School of Pathology and Laboratory Medicine

Molecular Biology

Molecular biology is concerned with studying living organisms at the molecular level.

Research group

Cell Signalling Group

 Researchers: Dr Jacky Chim, Ms Dian TeguhDr Jennifer TicknerW/Prof Jiake Xu 

The Cell Signalling Group is investigating cell signalling and bone pathobiology and diseases such as osteoporosis, Paget's disease of bone and tumour metastasis to bone.

The team utilises microarray technologies and proteomics and ENU-induced mutant mice models to identify novel molecules that regulate bone resorption, formation and repair.

Integrated molecular and genetic approaches help to identify genes that play a key role in bone homeostasis and disease process.

Osteoporosis is a major health problem in our ageing population, understanding the molecular mechanisms by which osteoclasts are regulated and communicate with osteoblasts will facilitate the development of treatments for lytic bone disorders.